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Vosaroxin Synthesis Essay

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EXPERT OPINION: Despite its structural dissimilarity, vosaroxin has mechanisms of action similar to the anthracyclines and anthracenediones already in use for the treatment of AML. However, unlike these agents, vosaroxin is not a P-gp substrate, appears to be unaffected by overexpression of P-gp or TP53 mutations, and may be useful in the treatment of AML, especially in the elderly.

Vosaroxin Synthesis Essay

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Vosaroxin (AG-7352, SPC-595, SNS 595, voreloxin) is a topoisomerase II inhibitor causing site-selective DNA damage.It is under phase III clinical trial investigation for acute myelogenous leukemia (AML) and ovarian cancer sponsored by Sunesis. Mechanism of action. Vosaroxin is a naphthyridine analog of the anticancer quinolone derivatives (AQDs), a class of compounds that has not been used.

Vosaroxin Synthesis Essay

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Vosaroxin Synthesis Essay

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Vosaroxin Synthesis Essay

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Synthetic lethality with the topoisomerase inhibitor irinotecan appears to occur when given to cancer patients with deficient expression of the DNA repair gene WRN. ( citation needed ) The analysis of 630 human primary tumors in 11 tissues shows that hypermethylation of the WRN CpG island promoter (with loss of expression of WRN protein) is a common event in tumorigenesis. (21).

Vosaroxin Synthesis Essay

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Vosaroxin Synthesis Essay

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Vosaroxin Synthesis Essay

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Vosaroxin Synthesis Essay

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